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KMID : 1134820060350081005
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Journal of the Korean Society of Food Science and Nutrition
2006 Volume.35 No. 8 p.1005 ~ p.1009
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Effects of the Extract of Hoelen on Serum Lipid Profiles in Mice
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Yun Hee-Jin
Cha Hyo-Mi
Kim Sung-Won
Shin Wan-Chul
Kim Hae-Gyoung
Choe Suck-Young
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Abstract
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The extracts of hoelen was evaluated for protective effects against the adverse effects of a high fat diet. Mice were divided into four groups; normal diet (control), high fat (HF) diet, high fat＋water extract (HF＋WE) and high fat＋ethanol extract (HF＋EE) and fed for 4 weeks. Food calorie consumptions were not significantly different between groups. Weight gain was significantly lower in HF＋EE than the high fat group. Also, liver weight was significantly lower in HF＋EE than the control group. The weight of epididymal fat tissue was 1.4 fold higher in high fat groups than control group. The concentration of serum triglyceride, total cholesterol and LDL-cholesterol increased in high fat group, but decreased by hoelen ethanol extract administration. Also serum HDL-cholesterol was decreased in the high fat group, but increased by the hoelen ethanol extract administration. Liver triglyceride and total cholesterol were not significantly different among groups. These data suggest that hoelen ethanol extract administration improves the serum lipid profiles of mice.
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KEYWORD
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high fat diet, hoelen, ethanol extract, lipid profiles
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